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Research: Herbal Remedies for Combating Irradiation

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Title: Herbal Remedies for Combating Irradiation: a Green Anti-irradiation Approach
Authors: Subramanion Jothy Lachumy, Chern Ein Oon, Subramanian Deivanai, Dharmaraj Saravanan, Soundararajan Vijayarathna, Yee Siew Choong, Chen Yeng, Lachimanan Yoga Latha, Sreenivasan Sasidharan 

Abstract
Plants play important roles in human life not only as suppliers of oxygen but also as a fundamental resource to sustain the human race on this earthly plane. Plants also play a major role in our nutrition by converting energy from the sun during photosynthesis. In addition, plants have been used extensively in traditional medicine since time immemorial. Information in the biomedical literature has indicated that many natural herbs have been investigated for their efficacy against lethal irradiation. Pharmacological studies by various groups of investigators have shown that natural herbs possess significant radioprotective activity. In view of the immense medicinal importance of natural product based radioprotective agents, this review aims at compiling all currently available information on radioprotective agents from medicinal plants and herbs, especially the evaluation methods and mechanisms of action. In this review we particularly emphasize on ethnomedicinal uses, botany, phytochemistry, mechanisms of action and toxicology. We also describe modern techniques for evaluating herbal samples as radioprotective agents. The usage of herbal remedies for combating lethal irradiation is a green anti-irradiation approach for the betterment of human beings without high cost, side effects and toxicity.
Plant speciesScientific namesComponentActivityReference
TomatoSolanum LycopersicumCarotenoids –lycopenesantioxidantGriffiths et al., 2005; Saraf and Kaur, 2010; Ravichandran et al., 2005
PapayaCarica papayaL-ascorbic acidAntioxidant and photoprotectiveVile, 1997
OrangeCitrus sinensisL-ascorbic acidantioxidantCimino et al., 2007
LemonCitrus limonL-ascorbic acidantioxidantApak et al., 2007
MangoMangifera indicaL-ascorbic acidantioxidant with anti-inflammatory and immunomodulatory activities.Song et al., 2013
PomegranatePunica granatumascorbic acidantioxidantKumar et al., 2009
CeleryApium graveolensFlavones – 5,7,4’- trihydroxystilibineantioxidant and ROS scavengerGriffiths et al., 2005; Svobova et al., 2003
Red cloverTrifolium pratenseIsoflavone – GenisteinInhibit UV induced peroxidase productionWidyarini et al., 2001
Green teaCamellia sinensisFlavanol – Epigallocatechin gallateantioxidant and ROS scavengerKatiyar et al., 2000; 2001; Katiyar and Elmets, 2001; Higdon, 2007; Li et al., 2009;
Sharangi, 2009; Kaur and Saraf, 2011b
Milk thistleSilybum marianumStilbenoid- Silybin,silibinin, silidianin, Silychristinanti-inflammatory and immunomodulatoryKatiyar, 2002; Fguyer et al., 2003; Vaid and Katiyar, 2010
GrapeVitis viniferaStilbenoid- Resveratrol, Flavanol -proanthocyanidinantioxidant and ROS scavengerAfaq et al., 2003; Saraf and Kaur, 2010; Aziz et al., 2005; Mantena and Katiyar, 2006
AppleMalus domesticaFlavanoid-QuercetinantioxidantErden Inal et al., 2001;
Korac and Khambholja, 2001
BoldoPeumus boldusQuercetin, Flavanol-catechin; aporphineantioxidant and anti-inflammatoryPeter et al., 2006; Russo et al., 2011
TurmericCurcuma longaPhenolic -curcuminanti-inflammatory, antiproliferative, Photoprotective effectSaraf and Kaur, 2010;
Garcia Bores and Avila, 2008
Aloe veraAloe barbadensisantraquinonesCellular repairWest and Zhu, 2003
RhubarbRheum rhaponticumstilbeneantioxidant and ROS scavengerSilveira et al., 2013
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Reference

Herbal Remedies for Combating Irradiation: a Green Anti-irradiation Approach
DOI:http://dx.doi.org/10.7314/APJCP.2013.14.10.5553

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