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What is Benzos (Benzodiazepines)?

Benzos (Benzodiazepines)

What is Benzo?

“Benzo” is a common shorthand for benzodiazepines, a class of psychoactive drugs used primarily to treat anxiety, insomnia, seizures, and muscle spasms. They work by enhancing the effect of the neurotransmitter GABA in the brain, producing a calming effect. Common examples include diazepam (Valium), alprazolam (Xanax), and lorazepam (Ativan).

Benzodiazepines are typically prescribed for short-term use due to risks of dependence, tolerance, and withdrawal symptoms. Side effects can include drowsiness, confusion, and impaired coordination. Misuse or long-term use can lead to addiction or serious health issues.

What Are Benzodiazepines Usually Prescribed For?

Benzodiazepines (commonly called “benzos”) are prescribed to treat a range of medical conditions due to their calming and sedative effects on the central nervous system. They enhance the activity of GABA, a neurotransmitter that inhibits brain activity, leading to relaxation. Common conditions they are prescribed for include:

  • Anxiety disorders: To manage symptoms of generalized anxiety disorder, panic disorder, or social anxiety (e.g., alprazolam/Xanax, lorazepam/Ativan).
  • Insomnia: Short-term treatment for sleep difficulties (e.g., temazepam/Restoril).
  • Seizure disorders: To control seizures, such as in epilepsy (e.g., diazepam/Valium, clonazepam/Klonopin).
  • Muscle spasms: To relieve muscle tension or spasticity (e.g., diazepam).
  • Alcohol withdrawal: To manage withdrawal symptoms and prevent seizures (e.g., chlordiazepoxide/Librium).
  • Sedation: For procedures like surgery or dental work (e.g., midazolam/Versed).

They are typically prescribed for short-term use (2-4 weeks) because of the risk of dependence with prolonged use.

How Do People Become Addicted to Benzodiazepines?

Benzodiazepine addiction can develop through both prescribed use and misuse. The process often involves:

  1. Physiological Dependence:
    • Regular use, even as prescribed, can lead to tolerance, where the body requires higher doses to achieve the same effect. This happens because the brain adapts to the drug’s presence, reducing GABA receptor sensitivity.
    • Within weeks, the body may rely on the drug to maintain normal function, leading to dependence.
  2. Psychological Dependence:
    • Users may feel they need the drug to cope with stress, anxiety, or sleep issues, reinforcing psychological reliance.
    • The calming effects can be reinforcing, leading some to use benzos to self-medicate for non-prescribed issues like stress or emotional distress.
  3. Misuse or Abuse:
    • Some individuals take benzos in higher doses, more frequently, or without a prescription to achieve euphoria or enhance the effects of other substances (e.g., opioids or alcohol).
    • Obtaining benzos illicitly or “doctor shopping” increases the risk of misuse.
  4. Risk Factors:
    • Long-term prescriptions (beyond 4 weeks).
    • History of substance abuse or mental health disorders.
    • Combining benzos with alcohol or other drugs, which amplifies effects and dependence risk.
    • Lack of medical supervision or inadequate monitoring.

Symptoms of Benzodiazepine Addiction

Addiction involves both physical dependence and behavioural changes. Symptoms include:

  • Physical and Psychological Symptoms:
    • Craving the drug or feeling unable to function without it.
    • Tolerance (needing higher doses for the same effect).
    • Withdrawal symptoms when not taking the drug, such as anxiety, irritability, sweating, tremors, nausea, insomnia, or seizures (in severe cases).
    • Continued use despite negative consequences (e.g., health issues, impaired work or relationships).
  • Behavioural Symptoms:
    • Taking more than prescribed or using someone else’s prescription.
    • Obsessing over obtaining or using the drug.
    • Neglecting responsibilities or hobbies in favour of drug use.
    • Doctor shopping or seeking multiple prescriptions.
    • Using benzos to cope with emotions or stress unrelated to the prescribed condition.
  • Cognitive and Physical Signs:
    • Memory problems, confusion, or difficulty concentrating.
    • Drowsiness, slurred speech, or impaired coordination.
    • Mood swings, depression, or increased anxiety when the drug wears off.

How Do People Quit or Stop Taking Benzodiazepines?

Quitting benzodiazepines can be challenging due to withdrawal risks, which can be severe or life-threatening (e.g., seizures). Stopping requires a careful, medically supervised approach. Steps include:

  1. Medical Supervision:
    • Consult a doctor or addiction specialist to create a personalized tapering plan. Abruptly stopping (“cold turkey”) is dangerous and can cause severe withdrawal symptoms like seizures, psychosis, or extreme anxiety.
    • Tapering involves gradually reducing the dose over weeks or months to minimize withdrawal effects.
  2. Tapering Process:
    • The doctor may reduce the dose by small increments (e.g., 10–25% every 1–2 weeks), depending on the drug, dose, and duration of use.
    • Switching to a longer-acting benzo (e.g., diazepam) during tapering can smooth the process, as it has a longer half-life and less intense withdrawal.
    • The timeline varies: short-term users may taper over weeks, while long-term users may need months.
  3. Supportive Therapies:
    • Cognitive Behavioural Therapy (CBT): Helps address underlying anxiety or insomnia, teaching coping strategies without relying on medication.
    • Counseling or Support Groups: Groups like Narcotics Anonymous or therapy can provide emotional support and accountability.
    • Lifestyle Changes: Stress management techniques (e.g., mindfulness, exercise, sleep hygiene) can reduce reliance on benzos.
  4. Managing Withdrawal:
    • Withdrawal symptoms (anxiety, insomnia, irritability, muscle pain, etc.) are common but can be managed with medical support.
    • In severe cases, doctors may use adjunct medications (e.g., anticonvulsants or antidepressants) to ease symptoms, though these are carefully selected to avoid new dependencies.
    • Inpatient detox or rehab may be recommended for severe addiction or co-occurring substance use.
  5. Aftercare and Relapse Prevention:
    • Ongoing therapy or support groups to maintain sobriety.
    • Addressing co-occurring mental health issues (e.g., anxiety, depression) to prevent relapse.
    • Avoiding triggers, such as stress or environments associated with drug use.
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Additional Notes

  • Risk of Relapse: Cravings and underlying conditions (e.g., anxiety) can make relapse common. Long-term support is crucial.
  • Individual Variation: The quitting process depends on the individual’s health, duration of use, and dosage. A healthcare provider tailors the plan.
  • Resources: If you or someone you know is struggling, contact a doctor, addiction specialist, or helplines like SAMHSA (1-800-662-HELP in the U.S.) for guidance.

Herbal alternatives

Herbal alternatives to benzodiazepines (benzos) can be considered for managing symptoms like anxiety, insomnia, or muscle tension, particularly for those seeking natural options with potentially lower risks of dependence.

Herbal remedies may not be as potent or fast-acting as benzos. Herbs are your best ally in the long-run when facing this and most other health issues. Take control of your health early and/or seek the assistance of an experienced, qualified herbalist or naturopathic doctor to help you before you reach the stage where you are recommended for a drug like benzos. Explore the root cause of the problem – why are you having anxiety, sleeplessness, or muscle spasms? Too often, we are trained not to trust ourselves, so we are always told “go to the doctor”, which is necessary in some instances. However, to cleanse the body and restore health is a daily decision you can make to create a healthier version of yourself.

Below are the most commonly studied herbal alternatives, organized by the conditions benzos typically treat.

For Anxiety

  1. Valerian Root (Valeriana officinalis):
    • Use: Traditionally used for anxiety and stress relief due to its calming effects.
    • Mechanism: May increase GABA levels in the brain, similar to benzos, though less potently.
    • Evidence: Small studies suggest mild anxiety reduction. Often combined with other herbs like lemon balm.
  2. Passionflower (Passiflora incarnata):
    • Use: Used for generalized anxiety and nervousness.
    • Mechanism: May modulate GABA receptors, promoting relaxation.
    • Evidence: A 2010 study found passionflower as effective as oxazepam (a benzo) for generalized anxiety disorder over 4 weeks, with fewer side effects.
    • Dosage: 300-450 mg of extract or 10-30 drops of tincture, 1-3 times daily.
    • Cautions: May cause dizziness or sedation. Not well-studied in pregnancy or with other 
  3. Ashwagandha (Withania somnifera):
    • Use: An adaptogen used in Ayurvedic medicine to reduce stress and anxiety.
    • Mechanism: May lower cortisol levels and modulate stress response.
    • Evidence: A 2019 study showed 600 mg/day of ashwagandha reduced anxiety scores significantly compared to placebo.
    • Dosage: 300-600 mg of standardized extract daily.
    • Cautions: May cause mild stomach upset or lower blood pressure. Avoid in pregnancy or with thyroid medications.
  4. Lemon Balm (Melissa officinalis):
    • Use: Calms nervousness and mild anxiety, often combined with valerian or chamomile.
    • Mechanism: May increase GABA activity and have mild sedative effects.
    • Evidence: Studies show benefits for mild anxiety, especially in combination with other herbs.
    • Dosage: 300-600 mg of extract or 1-2 cups of tea daily.
    • Cautions: Generally safe but may cause drowsiness or interact with thyroid medications.

For Insomnia

  1. Valerian Root:
    • Use: Widely used for insomnia, especially difficulty falling asleep.
    • Evidence: A 2020 review found valerian reduces sleep latency (time to fall asleep) in some cases, though results vary.
    • Dosage: 300-600 mg of extract 30-60 minutes before bed.
    • Cautions: Same as above. May not work for everyone; effects may take 2-4 weeks.
  2. Chamomile (Matricaria chamomilla):
    • Use: Promotes relaxation and mild sedation, often consumed as tea.
    • Mechanism: Contains apigenin, which may bind to GABA receptors.
    • Evidence: Studies suggest chamomile improves sleep quality, particularly in mild insomnia or anxiety-related sleep issues.
    • Dosage: 1-2 cups of tea (1-2 tsp dried chamomile per cup) or 220-1,600 mg of extract daily.
    • Cautions: Rare allergic reactions, especially in those sensitive to ragweed. Avoid with blood thinners.
  3. Lavender (Lavandula angustifolia):
    • Use: Used as aromatherapy or oral supplement for sleep and relaxation.
    • Mechanism: May influence GABA and serotonin pathways.
    • Evidence: A 2015 study found oral lavender (80 mg silexan) improved sleep quality in anxiety-related insomnia, comparable to low-dose benzos.
    • Dosage: 80-160 mg of silexan extract or 2-4 drops of essential oil for aromatherapy.
    • Cautions: Oral use may cause mild nausea or headache. Avoid applying undiluted oil to skin.
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For Muscle Spasms

  1. Cramp Bark (Viburnum opulus):
    • Use: Traditionally used for muscle cramps and spasms, including menstrual cramps.
    • Mechanism: May have antispasmodic properties, though exact mechanisms are unclear.
    • Evidence: Limited clinical data; mostly anecdotal use in herbal medicine.
    • Dosage: 1-2 tsp of dried bark as tea or 2-4 mL of tincture, 1-3 times daily.
    • Cautions: May cause stomach upset. Avoid in pregnancy without medical advice.
  2. Magnesium-Rich Herbs:
    • Use: Herbs like nettle or oatstraw provide magnesium, which may help with muscle cramps.
    • Evidence: Magnesium deficiency is linked to cramps; herbal sources may help, but supplements are more studied.
    • Dosage: Varies (e.g., 1-2 cups of nettle tea daily).
    • Cautions: High doses may cause diarrhea. Check for interactions with medications.

General Cautions and Considerations

  • Interactions: Herbs like valerian or ashwagandha can interact with medications (e.g., sedatives, antidepressants, or liver-metabolized drugs). 
  • Side Effects: While generally safer than benzos, herbs can cause side effects (e.g., drowsiness, GI upset).
  • Pregnancy/Breastfeeding: Many herbs are not well-studied in pregnancy; avoid unless guided by an experienced herbalist.
  • Tapering Benzos: If transitioning from benzos, do not stop abruptly. Work with a doctor to taper benzos while introducing herbs to avoid withdrawal.

Practical Tips

  • Start Low and Slow: Begin with low doses to assess tolerance and effects.
  • Combine with Non-Herbal Approaches: Pair herbs with CBT, exercise, or meditation for better outcomes.
  • Professional Guidance: Consult a naturopath, herbalist, or doctor, especially for chronic conditions or polypharmacy.

References

  1. Sarris, J., et al. (2013). “Kava for the treatment of generalized anxiety disorder: A randomized, double-blind, placebo-controlled study.” Journal of Clinical Psychopharmacology, 33(5), 643–648.
    • Supports kava’s efficacy for mild to moderate anxiety, comparable to low-dose benzodiazepines.
    • DOI: 10.1097/JCP.0b013e318291be67
  2. Wohlmuth, H., et al. (2010). “Passionflower (Passiflora incarnata) in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam.” Journal of Clinical Pharmacy and Therapeutics, 35(5), 559–565.
    • Demonstrates passionflower’s effectiveness for anxiety with fewer side effects than oxazepam.
    • DOI: 10.1111/j.1365-2710.2009.01124.x
  3. Pratte, M. A., et al. (2019). “An alternative treatment for anxiety: A systematic review of human trial results reported for the Ayurvedic herb ashwagandha (Withania somnifera).” Journal of Alternative and Complementary Medicine, 25(12), 1117–1125.
    • Confirms ashwagandha’s role in reducing anxiety and stress.
    • DOI: 10.1089/acm.2019.0091
  4. Bent, S., et al. (2006). “Valerian for sleep: A systematic review and meta-analysis.” American Journal of Medicine, 119(12), 1005–1012.
    • Reviews valerian’s mixed but promising effects on insomnia.
    • DOI: 10.1016/j.amjmed.2006.02.026
  5. Kasper, S., et al. (2015). “Efficacy of orally administered Lavandula angustifolia (silexan) in the treatment of anxiety-related insomnia.” International Clinical Psychopharmacology, 30(5), 274–281.
    • Shows lavender’s benefits for sleep in anxiety-related insomnia.
    • DOI: 10.1097/YIC.0000000000000083
  6. National Center for Complementary and Integrative Health (NCCIH). (2020). “Herbs at a Glance: Chamomile.”
  7. Kennedy, D. O., et al. (2006). “Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory-induced stress.” Phytotherapy Research, 20(2), 96–102.
    • Supports lemon balm’s calming effects, especially in combination with valerian.
    • DOI: 10.1002/ptr.1787
  8. Natural Medicines Database. (2023). “Monographs on Valerian, Kava, Passionflower, and Cramp Bark.”

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